1. March 18, 1925 – Tri-state area of Missouri, Illinois and Indiana – 695 fatalities.
2. May 6, 1840 – Natchez, Mississippi – 317 fatalities.
3. May 27, 1896 – St. Louis, Missouri – 255 fatalities.
4. April 5, 1936 – Tupelo, Mississippi – 216 fatalities.
5. April 6, 1936 – Gainesville, Georgia – 203 fatalities.
6. April 9, 1947 – Woodward, Oklahoma – 181 fatalities.
7. May 22, 2011 – Joplin, Missouri – 158 fatalities.
8. April 24, 1908 – Amite, Louisiana and Purvis, Mississippi – 143 fatalities.
9. June 12, 1899 – New Richmond, Wisconsin – 117 fatalities.
10. June 8, 1953 – Flint, Michigan – 116 fatalities.